Scopus Author ID: 22934763900
Epigenetic regulation of muscle progenitor cells during skeletal muscle regeneration and disease
The research in our lab aims to dissect the epigenetic mechanisms governing muscle progenitor cells’ fate determination. We are interested in studying how histone modifying enzymes control stem cells’ alternative transcriptional programs and fates. We aim to reveal how these epigenetic players control skeletal muscle differentiation/regeneration, with the goal to understand how these processes are deregulated in muscle disorders, such as muscular dystrophies and malignancies of muscular origin as rhabdomyosarcomas.
Keywords: muscle stem cells, skeletal muscle differentiation, fibro-adipogenic progenitors, epigenetics, chromatin, methyltransferases, muscular dystrophy, rhabdomyosarcoma.
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