Mozzetta Chiara
Informazioni Personali
Researcher identifiers:
ORCID: orcid.org/0000-0002-7147-7266
Scopus Author ID: 22934763900
Research activity:
Epigenetic regulation of muscle progenitor cells during skeletal muscle regeneration and disease
The research in our lab aims to dissect the epigenetic mechanisms governing muscle progenitor cells’ fate determination. We are interested in studying how histone modifying enzymes control stem cells’ alternative transcriptional programs and fates. We aim to reveal how these epigenetic players control skeletal muscle differentiation/regeneration, with the goal to understand how these processes are deregulated in muscle disorders, such as muscular dystrophies and malignancies of muscular origin as rhabdomyosarcomas.
Keywords: muscle stem cells, skeletal muscle differentiation, fibro-adipogenic progenitors, epigenetics, chromatin, methyltransferases, muscular dystrophy, rhabdomyosarcoma.
Project funded:
- Scientific Independence of Young Researcher (SIR), Italian Ministry of University and Research (MIUR): Role of Prdm16 and histone H3 lysine 9 methyltransferases G9a/GLP in the epigenetic regulation of Fibro-Adipogenic Progenitors fate choice in dystrophic muscles
- MyFIRST AIRC grant, Italian Association for Cancer Research (AIRC): Histone H3K9 Methyltransferase G9a in the patho-epigenetic deregulation of rhabdomyosarcoma
- “RESEARCH - Riposizionamento E Sviluppo Economico di Attività di Ricerca su Composti HDACi”. Project co-funded by EU and Regione Lazio (Program LIFE 2020). This project, run in collaboration with IRBM (Pomezia, Italy), aims to perform pre-clinical development of specific inhibitors for class I HDACs in cell and murine models of skeletal muscle regeneration and Duchenne Muscular Dystrophy (DMD). More specific info at: http://www.irbm.com/italian-funding/life2020-research
