Dipartimento di Biologia e
Biotecnologie Charles Darwin

Publications acknowledging the facility:

2020

• Sardina F, Monteonofrio L, Ferrara M, Magi F, Soddu S, Rinaldo C. 2020. HIPK2 is required for midbody remnant removal through autophagy-mediated degradation. Front Cell Dev Biol. 8:572094.
• Di Martile M, Gabellini C, Desideri M, Matraxia M, Farini V, Valentini E,Carradori S, Ercolani C, Buglioni S, Secci D, Andreazzoli M, Del Bufalo D,Trisciuoglio D. 2020. Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells. J Exp Clin Cancer Res. 39(1):103. doi: 10.1186/s13046-020-01604-z.
• Gatti V, Ferrara M, Virdia I, Matteoni S, Monteonofrio L, di Martino S, Diodoro MG, Di Rocco G, Rinaldo C*, Soddu S. 2020. An Alternative Splice Variant of HIPK2 with Intron Retention Contributes to Cytokinesis. Cells. 9(2):484. *co-last author.
• Naso FD, Sterbini V, Crecca E, Asteriti IA, Russo AD, Giubettini M, Cundari E, Lindon C, Rosa A, Guarguaglini G. 2020. Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit. Cells. 9(2). pii: E374. doi: 10.3390/cells9020374.
• Licursi V, Anzellotti S, Favaro J, Sineri S, Carucci N, Cundari E, Fiore M, Guarguaglini G, Pippa S, Nisi PS, Vernì F, Biagioni S, Cacci E, Amendola R, Lupo G, Negri R. 2020. X-ray irradiated cultures of mouse cortical neural stem/progenitor cells recover cell viability and proliferation with dose-dependent kinetics. Sci Rep. 10(1):6562. doi: 10.1038/s41598-020-63348-2.
• Bellisai C, Sciamanna I, Rovella P, Giovannini D, Baranzini M, Pugliese GM, Zeya Ansari MS, Milite C, Sinibaldi-Vallebona P, Cirilli R, Sbardella G, Pichierri P, Trisciuoglio D, Lavia P, Serafino A, Spadafora C. 2020. Reverse transcriptase inhibitors promote the remodelling of nuclear architecture and induce autophagy in prostate cancer cells. Cancer Lett.; 478:133-45. 
• Degrassi F, Damizia M, Lavia P. The mitotic apparatus and kinetochores in microcephaly and neurodevelopmental diseases. Cells 2019; 9(1):49.
• Verrico A, Rovella P, Di Francesco L, Damizia M, Staid DS, Le Pera L, Schininà ME, Lavia P. 2020. Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region. Oncogene. 39:454-68.

2019

• Monteonofrio L, Valente D, Ferrara M, Camerini S, Miscione R, Crescenzi M, Rinaldo C, Soddu S. 2019. HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis. Oncogene. 37:3562-3574.
• Traversi G, Staid DS, Fiore M, Percario Z, Trisciuoglio D, Antonioletti R, Morea V, Degrassi F, Cozzi R. 2019. A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin. Cell Div. 14:3. eCollection 2019.

2018

• Di Francesco L, Verrico A, Asteriti IA, Rovella P, Cirigliano P, Guarguaglini  G, Schininà ME, Lavia P. 2018. Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays. Sci Rep. 8:1850. doi: 10.1038/s41598-018-19351-9.
• Ferrara M., Sessa G., Fiore M., Bernard F., Asteriti I.A., Cundari E.,  Colotti G.,  Ferla S., Desideri M., Buglioni S.,  Trisciuoglio D.,   Del Bufalo D., Brancale A., Degrassi  F. 2018. Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization. Oncogene. 37:231-240. doi: 10.1038/onc.2017.320.
• La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R. 2018. New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer  cell growth inhibitors. Eur J Med Chem. 152:283-297.

2017

• Traversi G, Fiore M, Percario Z, Degrassi F, Cozzi R. 2017. The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis. Mol Carcinog. 56:1117-26.
• Barbiero I, Valente D, Chandola C, Magi F, Bergo A, Monteonofrio L, Tramarin M, Fazzari M, Soddu S, Landsberger N, Rinaldo C, Kilstrup-Nielsen C. 2017. CDKL5 localizes at the centrosome and midbody and is required for faithful cell division. Sci Rep.;7:6228. doi: 10.1038/s41598-017-05875-z.
• Abbruzzese C, Catalogna G, Gallo E, di Martino S, Mileo AM, Carosi M, Dattilo  V, Schenone S, Musumeci F, Lavia P, Perrotti N, Amato R, Paggi MG. 2017. The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme. Oncotarget 8:110743-110755. doi: 10.18632/oncotarget.22500.
• Scaglione A, Montemiglio LC, Parisi G, Asteriti IA, Bruni R, Cerutti G, Testi C, Savino C, Mancia F, Lavia P, Vallone B. 2017. Subcellular localization of the five members of the human steroid 5α-reductase family. Biochim Open. 4:99-106. doi: 10.1016/j.biopen.2017.03.003. 
• Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P. 2017. Importin beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function. J Cell Sci. Jun 9. pii:  jcs.197905. doi: 10.1242/jcs.197905. [Epub ahead of print]
• I.A. Asteriti, F. Daidone, G. Colotti, S. Rinaldo, P. Lavia, G. Guarguaglini and A. Paiardini 2017. Identification of small molecule inhibitors of the Aurora-A/TPX2 complex. Oncotarget, 8:32117-32133.
• Colicchia V., Petroni M, Guarguaglini G, Sardina F, Roncero MS, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A and Giuseppe G. 2017. PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma" Oncogene. 36:4682-4691. doi: 10.1038/onc.2017.40.
• Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P. 2017 Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules. Oncotarget  Feb 1. doi: 10.18632/oncotarget.14980
• Mosca L., Falvo E., Ceci P., Poser E., Genovese I., Guarguaglini G. and Colotti G. 2017. Use of Ferritin-Based Metal-Encapsulated Nanocarriers as Anticancer Agents. Appl. Sci. 7: 101; doi:10.3390/app7010101

2016

• Del Vecchio G, De Vito F, Saunders SJ, Risi A, Mannironi C, Bozzoni I, Presutti C. 2016. RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA. RNA 22:1510-21.
• Sánchez-Lamar A, Piloto-Ferrer J, Fiore M, Stano P, Cozzi R, Tofani D, Cundari E, Francisco M, Romero A, González ML, Degrassi F. 2016. Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin. J Ethnopharmacol. 194:781-8.
• De Santis Puzzonia M., Cozzolino A.M., Grassi G., Bisceglia F., Strippoli R., Guarguaglini G., Citarella F., Sacchetti B., Tripodi M., Marchetti A., Amicone L. 2016. TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure. PLoS One. 11:e0167158.
• Gallini S, Carminati M, De Mattia F, Pirovano L, Martini E, Amanda Oldani A, Asteriti IAA, Guarguaglini G, Mapelli M. 2016. NuMA phosphorylation by Aurora-A orchestrates spindle orientation. Curr. Biol, 26:458-69

2015

• de Turris V, Teloni R, Chiani P, Bromuro C, Mariotti S, Pardini M, Nisini R, Torosantucci A, Gagliardi MC. 2015. Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses. PLoS One. 10:e0142531. eCollection 2015.
• La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R. 2015. New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. J Med Chem. 58:5789-807.
• Pierantoni GM, Conte A, Rinaldo C, Tornincasa M, Gerlini R, Federico A, Valente D, Medico E, Fusco A. 2015. Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. Oncotarget. 6:17342-53
• Valente D, Bossi G, Moncada A, Tornincasa M, Indelicato S, Piscuoglio S, Karamitopoulou ED, Bartolazzi A, Pierantoni GM, Fusco A, Soddu S, Rinaldo C. 2015. HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity. Oncotarget 6:10320-34.
• Gonzalez L, De Santis Puzzonia M, Ricci R, Aureli F, Guarguaglini G, Cubadda F, Leyns L, Cundari E, Kirsch-Volders M. 2015. Amorphous silica nanoparticles alter microtubule dynamics and cell migration. Nanotoxicology. 9: 729-36. 

2014

• Stellas D, Souliotis VL, Bekyrou M, Smirlis D, Kirsch-Volders M, Degrassi F, Cundari E, Kyrtopoulos SA. 2014. Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability. Mutat Res. 769:59-68.
• Orticello M, Fiore M, Totta P, Desideri M, Barisic M, Passeri D, Lenzi J, Rosa A, Orlandi A, Maiato H, Del Bufalo D, Degrassi F. 2015. A N-terminus modified Hec1 suppresses tumor growth by interfering with kinetochore microtubule dynamics Oncogene, 34:3325-35.
• Lionetti V., Cervone F., De Lorenzo G. 2014. A lower content of de-methylesterified homogalacturonan improves enzymatic cell separation and isolation of mesophyll protoplasts in Arabidopsis. Phytochemistry, et al : pii: S0031-9422(14)00312-4.
• La Regina G., Bai R., Coluccia A., Famiglini V., Pelliccia S., Passacantilli S., Mazzoccoli C., Ruggieri V., Sisinni L., Bolognesi A., Rensen W.M., Miele A., Nalli M., Alfonsi R., Di Marcotullio L., Gulino A., Brancale A., Novellino E., Dondio G.M., Vultaggio S., Varasi M., Mercurio C., Hamel E., Lavia P., Silvestri R.  2014.  New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. J Med Chem.57:6531-52.
• Asteriti I.A.,  Di Cesare E., De Mattia F., Hilsenstein V.,  Neumann B., Cundari E.,   Lavia P.^, Guarguaglini G. 2014.The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy. Oncotarget 5:6229-42.
• Messina G, Damia E, Fanti L, Atterrato MT, Celauro E, Mariotti FR, Accardo MC, Walther M, Vernì F, Picchioni D, Moschetti R, Caizzi R, Piacentini L, Cenci G, Giordano E, Dimitri P. 2014. Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization. J Cell Sci. 127:2577-88.
• Guarguaglini G, de Turris V, Lavia P. 2014. Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells. Methods Mol  Biol. 1120:241-52.