Pubblicazioni Microscopy Center

Publications acknowledging the facility:

2019

  • Monteonofrio L, Valente D, Ferrara M, Camerini S, Miscione R, Crescenzi M, Rinaldo C, Soddu S. 2019. HIPK2 and extrachromosomal histone H2B are separately recruited by Aurora-B for cytokinesis. Oncogene. 37:3562-3574.
  • Traversi G, Staid DS, Fiore M, Percario Z, Trisciuoglio D, Antonioletti R, Morea V, Degrassi F, Cozzi R. 2019. A novel resveratrol derivative induces mitotic arrest, centrosome fragmentation and cancer cell death by inhibiting γ-tubulin. Cell Div. 14:3. eCollection 2019.

2018

  • Di Francesco L, Verrico A, Asteriti IA, Rovella P, Cirigliano P, Guarguaglini  G, Schininà ME, Lavia P. 2018. Visualization of human karyopherin beta-1/importin beta-1 interactions with protein partners in mitotic cells by co-immunoprecipitation and proximity ligation assays. Sci Rep. 8:1850. doi: 10.1038/s41598-018-19351-9.
  • Ferrara M., Sessa G., Fiore M., Bernard F., Asteriti I.A., Cundari E.,  Colotti G.,  Ferla S., Desideri M., Buglioni S.,  Trisciuoglio D.,   Del Bufalo D., Brancale A., Degrassi  F. 2018. Small molecules targeted to the microtubule-Hec1 interaction inhibit cancer cell growth through microtubule stabilization. Oncogene. 37:231-240. doi: 10.1038/onc.2017.320.
  • La Regina G, Bai R, Coluccia A, Naccarato V, Famiglini V, Nalli M, Masci D, Verrico A, Rovella P, Mazzoccoli C, Da Pozzo E, Cavallini C, Martini C, Vultaggio S, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R. 2018. New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer  cell growth inhibitors. Eur J Med Chem. 152:283-297.

2017

  • Traversi G, Fiore M, Percario Z, Degrassi F, Cozzi R. 2017. The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis. Mol Carcinog. 56:1117-26.
  • Barbiero I, Valente D, Chandola C, Magi F, Bergo A, Monteonofrio L, Tramarin M, Fazzari M, Soddu S, Landsberger N, Rinaldo C, Kilstrup-Nielsen C. 2017. CDKL5 localizes at the centrosome and midbody and is required for faithful cell division. Sci Rep.;7:6228. doi: 10.1038/s41598-017-05875-z.
  • Abbruzzese C, Catalogna G, Gallo E, di Martino S, Mileo AM, Carosi M, Dattilo  V, Schenone S, Musumeci F, Lavia P, Perrotti N, Amato R, Paggi MG. 2017. The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme. Oncotarget 8:110743-110755. doi: 10.18632/oncotarget.22500.
  • Scaglione A, Montemiglio LC, Parisi G, Asteriti IA, Bruni R, Cerutti G, Testi C, Savino C, Mancia F, Lavia P, Vallone B. 2017. Subcellular localization of the five members of the human steroid 5α-reductase family. Biochim Open. 4:99-106. doi: 10.1016/j.biopen.2017.03.003. 
  • Gilistro E, de Turris V, Damizia M, Verrico A, Moroni S, De Santis R, Rosa A, Lavia P. 2017. Importin beta and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function. J Cell Sci. Jun 9. pii:  jcs.197905. doi: 10.1242/jcs.197905. [Epub ahead of print]
  • I.A. Asteriti, F. Daidone, G. Colotti, S. Rinaldo, P. Lavia, G. Guarguaglini and A. Paiardini 2017. Identification of small molecule inhibitors of the Aurora-A/TPX2 complex. Oncotarget, 8:32117-32133.
  • Colicchia V., Petroni M, Guarguaglini G, Sardina F, Roncero MS, Carbonari M, Ricci B, Heil C, Capalbo C, Belardinilli F, Coppa A, Peruzzi G, Screpanti I, Lavia P, Gulino A and Giuseppe G. 2017. PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma" Oncogene. 36:4682-4691. doi: 10.1038/onc.2017.40.
  • Di Cesare E, Verrico A, Miele A, Giubettini M, Rovella P, Coluccia A, Famiglini V, La Regina G, Cundari E, Silvestri R, Lavia P. 2017 Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules. Oncotarget  Feb 1. doi: 10.18632/oncotarget.14980
  • Mosca L., Falvo E., Ceci P., Poser E., Genovese I., Guarguaglini G. and Colotti G. 2017. Use of Ferritin-Based Metal-Encapsulated Nanocarriers as Anticancer Agents. Appl. Sci. 7: 101; doi:10.3390/app7010101

2016

  • Del Vecchio G, De Vito F, Saunders SJ, Risi A, Mannironi C, Bozzoni I, Presutti C. 2016. RNA-binding protein HuR and the members of the miR-200 family play an unconventional role in the regulation of c-Jun mRNA. RNA 22:1510-21.
  • Sánchez-Lamar A, Piloto-Ferrer J, Fiore M, Stano P, Cozzi R, Tofani D, Cundari E, Francisco M, Romero A, González ML, Degrassi F. 2016. Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin. J Ethnopharmacol. 194:781-8.
  • De Santis Puzzonia M., Cozzolino A.M., Grassi G., Bisceglia F., Strippoli R., Guarguaglini G., Citarella F., Sacchetti B., Tripodi M., Marchetti A., Amicone L. 2016. TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure. PLoS One. 11:e0167158.
  • Gallini S, Carminati M, De Mattia F, Pirovano L, Martini E, Amanda Oldani A, Asteriti IAA, Guarguaglini G, Mapelli M. 2016. NuMA phosphorylation by Aurora-A orchestrates spindle orientation. Curr. Biol, 26:458-69

2015

  • de Turris V, Teloni R, Chiani P, Bromuro C, Mariotti S, Pardini M, Nisini R, Torosantucci A, Gagliardi MC. 2015. Candida albicans Targets a Lipid Raft/Dectin-1 Platform to Enter Human Monocytes and Induce Antigen Specific T Cell Responses. PLoS One. 10:e0142531. eCollection 2015.
  • La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Verrico A, Miele A, Monti L, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Ricci B, Soriani A, Santoni A, Caraglia M, Porto S, Da Pozzo E, Martini C, Brancale A, Marinelli L, Novellino E, Vultaggio S, Varasi M, Mercurio C, Bigogno C, Dondio G, Hamel E, Lavia P, Silvestri R. 2015. New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. J Med Chem. 58:5789-807.
  • Pierantoni GM, Conte A, Rinaldo C, Tornincasa M, Gerlini R, Federico A, Valente D, Medico E, Fusco A. 2015. Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. Oncotarget. 6:17342-53
  • Valente D, Bossi G, Moncada A, Tornincasa M, Indelicato S, Piscuoglio S, Karamitopoulou ED, Bartolazzi A, Pierantoni GM, Fusco A, Soddu S, Rinaldo C. 2015. HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity. Oncotarget 6:10320-34.
  • Gonzalez L, De Santis Puzzonia M, Ricci R, Aureli F, Guarguaglini G, Cubadda F, Leyns L, Cundari E, Kirsch-Volders M. 2015. Amorphous silica nanoparticles alter microtubule dynamics and cell migration. Nanotoxicology. 9: 729-36. 

2014

  • Stellas D, Souliotis VL, Bekyrou M, Smirlis D, Kirsch-Volders M, Degrassi F, Cundari E, Kyrtopoulos SA. 2014. Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability. Mutat Res. 769:59-68.
  • Orticello M, Fiore M, Totta P, Desideri M, Barisic M, Passeri D, Lenzi J, Rosa A, Orlandi A, Maiato H, Del Bufalo D, Degrassi F. 2015. A N-terminus modified Hec1 suppresses tumor growth by interfering with kinetochore microtubule dynamics Oncogene, 34:3325-35.
  • Lionetti V., Cervone F., De Lorenzo G. 2014. A lower content of de-methylesterified homogalacturonan improves enzymatic cell separation and isolation of mesophyll protoplasts in Arabidopsis. Phytochemistry, et al : pii: S0031-9422(14)00312-4.
  • La Regina G., Bai R., Coluccia A., Famiglini V., Pelliccia S., Passacantilli S., Mazzoccoli C., Ruggieri V., Sisinni L., Bolognesi A., Rensen W.M., Miele A., Nalli M., Alfonsi R., Di Marcotullio L., Gulino A., Brancale A., Novellino E., Dondio G.M., Vultaggio S., Varasi M., Mercurio C., Hamel E., Lavia P., Silvestri R.  2014.  New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. J Med Chem.57:6531-52.
  • Asteriti I.A.,  Di Cesare E., De Mattia F., Hilsenstein V.,  Neumann B., Cundari E.,   Lavia P., Guarguaglini G. 2014.The Aurora-A inhibitor MLN8237 affects multiple mitotic processes and induces dose-dependent mitotic abnormalities and aneuploidy. Oncotarget 5:6229-42.
  • Messina G, Damia E, Fanti L, Atterrato MT, Celauro E, Mariotti FR, Accardo MC, Walther M, Vernì F, Picchioni D, Moschetti R, Caizzi R, Piacentini L, Cenci G, Giordano E, Dimitri P. 2014. Yeti, an essential Drosophila melanogaster gene, encodes a protein required for chromatin organization. J Cell Sci. 127:2577-88.
  • Guarguaglini G, de Turris V, Lavia P. 2014. Immunofluorescence methods in studies of the GTPase RAN and its effectors in interphase and in mitotic cells. Methods Mol  Biol. 1120:241-52.

2013

  • Fiore M, Mattiuzzo M, Mancuso G, Totta P, Degrassi F. 2013. The pesticide dichlorvos disrupts mitotic division by delocalizing the kinesin Kif2a from centrosomes. Environ Mol Mutagen. 54:250-60.
  • Cifani N, Pompili B, Anile M, Patella M, Diso D, Venuta F, Cimmino G, Quattrucci S, Di Domenico E, Ascenzioni F, Del Porto P. 2013. Reactive oxygen species mediated P. Aeruginosa killing is functional in human CF macrophages. PlosOne, 8:e71717.
  • Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F, Brenner DA, Kisseleva T, Bianco P, Tripodi M. 2013. Evidence for a common progenitor of epithelial and mesenchymal components of the liver.
    Cell Death Differ. 20:1116-23. 

2012

  • Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio AM, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M. 2012. Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium. PLoS One. 7:e51109. 
  • Rinaldo C, Moncada A, Gradi A, Ciuffini L, D'Eliseo D, Siepi F, Prodosmo A, Giorgi A, Pierantoni GM, Trapasso F, Guarguaglini G, Bartolazzi A, Cundari E, Schininà ME, Fusco A, Soddu S. 2012. HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody. Mol Cell  47:87-98.
  • Chronopoulou L, Togna AR, Guarguaglini G, Masci G, Giammaruco F, Togna GI and Palocci C. 2012. Self-assembling peptide hydrogels promote microglial cells proliferation and NGF production. Soft matter 8: 5784-5790.
  • Ooi WF, Re A, Sidarovich V, Canella V, Arseni N, Adami V, Guarguaglini G, Giubettini M, Scaruffi P, Stigliani S, Lavia P, Tonini GP, Quattrone A. 2012. Segmental chromosome aberrations converge on overexpression of mitotic spindle regulatory genes in high-risk neuroblastoma. Genes Chromosomes Cancer 51:545-56. 
  • Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schininà ME, Lavia P. 2012. Importin-β negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores. J Cell Biol. 196:435-50.

2011

  • La Regina G, Bai R, Rensen W, Coluccia A, Piscitelli F, Gatti V, Bolognesi A, Lavecchia A, Granata I, Porta A, Maresca B, Soriani A, Iannitto ML, Mariani M, Santoni A, Brancale A, Ferlini C, Dondio G, Varasi M, Mercurio C, Hamel E, Lavia P, Novellino E, Silvestri R. 2011. Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. J Med Chem. 54:8394-406.
  • Asteriti IA, Giubettini M, Lavia P, Guarguaglini G. 2011. Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces. Mol Cancer  10:131
  • Giubettini M, Asteriti IA, Scrofani J, De Luca M, Lindon C, Lavia P and  Guarguaglini G. 2011. Control of Aurora-A stability through interaction with TPX2. J Cell Sci.  124:113-22.

2010

  • Ciciarello M, Roscioli E, Di Fiore B, Di Francesco L, Sobrero F, Bernard D, Mangiacasale R, Harel A, Schininà ME and Lavia P. 2010.  Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells. Chromosoma  119:651-68.

 

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